Recommended Definitions of Aggressive Prostate Cancer for Etiologic Epidemiologic Research

LM Hurwitz; I Agalliu; D Albanes; KH Barry; SI Berndt; Q Cai; C Chen; I Cheng; JM Genkinger; GG Giles; J Huang; CE Joshu; TJ Key; S Knutsen; S Koutros; H Langseth; SX Li; RJ MacInnis; SC Markt; KL Penney; A Perez-Cornago; TE Rohan; SA Smith-Warner; MJ Stampfer; KH Stopsack; CM Tangen; RC Travis; SJ Weinstein; L Wu; EJ Jacobs; LA Mucci; MB Cook

Journal article

Recommended Definitions of Aggressive Prostate Cancer for Etiologic Epidemiologic Research

LM Hurwitz, I Agalliu, D Albanes, KH Barry, SI Berndt, Q Cai, C Chen, I Cheng, JM Genkinger, GG Giles, J Huang, CE Joshu, TJ Key, S Knutsen, S Koutros, H Langseth, SX Li, RJ MacInnis, SC Markt, KL Penney Show all

Journal of the National Cancer Institute | Published : 2021

DOI: 10.1093/jnci/djaa154

Abstract

Background: In the era of widespread prostate-specific antigen testing, it is important to focus etiologic research on the outcome of aggressive prostate cancer, but studies have defined this outcome differently. We aimed to develop an evidence-based consensus definition of aggressive prostate cancer using clinical features at diagnosis for etiologic epidemiologic research. Methods: Among prostate cancer cases diagnosed in 2007 in the National Cancer Institute's Surveillance, Epidemiology, and End Results-18 database with follow-up through 2017, we compared the performance of categorizations of aggressive prostate cancer in discriminating fatal prostate cancer within 10 years of diagnosis, p..

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University of Melbourne Researchers

Graham Giles Author

Robert MacInnis Author

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Grants

Awarded by National Cancer Institute

Funding Acknowledgements

This research was supported by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, Department of Health and Human Services. Investigators were also supported by the following grants: U01-CA164975, U01-CA182883, U01-CA167552, P30CA006973, P30-CA006516, P30-CA008748, U01-CA063673, UM1-CA167462, U01-CA167462, K07-CA230182 (NCI/NIH/HHS), W81XWH-18-1-0330 (DOD), C8221/A19170, C8221/A29017 (Cancer Research UK), a University of Hawaii Cancer Center Seed Grant, Prostate Cancer Foundation Young Investigator Awards, and Program Grants 209057 and 1074383 and an Enabling Grant 396414 from the Australian National Health and Medical Research Council.